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Dynamics of Cas10 Govern Discrimination between Self and Non-self in Type III CRISPR-Cas Immunity
Authors:Ling Wang  Charlie Y Mo  Michael R Wasserman  Jakob T Rostøl  Luciano A Marraffini  Shixin Liu
Institution:1. Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA;2. Laboratory of Bacteriology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
Abstract:
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  • Keywords:adaptive immunity  type III CRISPR-Cas  single-molecule FRET  conformational dynamics  target specificity  self/non-self discrimination  crRNA tag  protospacer  Cas10
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