The lingering enigma of the allelic exclusion mechanism |
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| Authors: | Mostoslavsky Raul Alt Frederick W Rajewsky Klaus |
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| Affiliation: | Howard Hughes Medical Institute, The Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. |
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| Abstract: | B lymphocytes produce diverse antibody specificities by "randomly" assembling antibody genes from germline segments. Yet, though each B lymphocyte has multiple allelic loci for the different antibody chains, each clonally derived mature B lymphocyte expresses a single species of antibody with a unique specificity via a process termed allelic exclusion. Despite some progress, the precise mechanism of allelic exclusion remains an enigma. |
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