Selenium,Lead, and Cadmium Levels in Renal Failure Patients in China |
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Authors: | Bing Chen Ludwig V Lamberts Geert J Behets Tingting Zhao Mingxiang Zhou Gang Liu Xianghua Hou Guangju Guan Patrick C D’Haese |
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Institution: | (1) Laboratory of Pathophysiology, Faculties of Medicine and Biomedical and Pharmaceutical and Veterinary Sciences, University of Antwerp, Campus CDE-Universiteitsplein 1 (building T3), B-2610 Wilrijk, Antwerp, Belgium;(2) Department of Nephrology, The Second Affiliated Hospital, Shandong University, 247#, Beiyuan Road, Jinan, 250033, People’s Republic of China;(3) Department of Respiratory Medicine, Shandong Provincial Chest Hospital, Jinan, 250013, People’s Republic of China |
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Abstract: | Whole blood and serum samples of Chinese stable chronic renal failure (CRF) patients (n = 81), hemodialysis patients (n = 135), posttransplant patients (n = 60), and subjects with normal renal function (NRF; N = 42) were collected, as well as water and dialysate samples from five dialysis centers. The concentration of selenium (Se),
lead (Pb), and cadmium (Cd) was measured by atomic absorption spectrometry. The mean serum Se levels in patients with different
degrees of renal failure were significantly lower than those of subjects with NRF (p < 0.01). Pb levels were not increased in renal failure patients, while the Cd levels in patients with various degrees of
renal failure were higher than in subjects with NRF (p < 0.05). After correcting the results of Pb and Cd for hematocrit (Hct) however, Pb levels of dialysis patients were also
increased. In the dialysis population under study, blood Pb and Cd levels were closely related to the time on dialysis, while
contamination of the final dialysate may also contribute to the increased blood Cd and to a less extent Pb levels. Correction
for Hct may be recommended to accurately compare blood Pb and Cd levels in dialysis patients and CRF patients with varying
degrees of anemia to those of subjects with NRF. |
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Keywords: | Trace element Selenium Lead Cadmium Chronic renal failure Toxicity Dialysis |
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