模式识别受体介导炎症信号通路及人参属植物皂苷抗炎研究进展

炎症是一种非常常见而又十分重要的基本病理过程,临床表现为红、肿、痛,其伴随着疾病的发生而产生,同时又会加重疾病的发展,有些甚至会产生恶性肿瘤。在炎症分子机制的研究中,已发现多条重要的信号通路,其中模式识别受体介导的炎症信号通路在很多疾病中都扮演着重要的角色,基于这些重要的炎症信号通路中的关键分子筛选抗炎药物受到广泛关注。人参属植物是名贵的中药材,具有很高的药用价值。我国人参属植物主要包括:人参、三七、竹节参及其变种珠子参等。皂苷是人参属植物的主要活性成分之一,药理研究显示其具有良好的抗炎效果。本文就此将近年来模式识别受体介导的炎症信号通路及人参属植物皂苷抗炎的研究成果进行总结,为抗炎药物研究提供理论基础。

Research Progress in Inflammation Signaling Mediated by the Pattern Recognition Receptors and Anti-inflammatory of Saponins fromPanax Ginseng

Inflammation is a very common basic pathological process, the clinical manifestations of red, swelling, and pain. It comes with the disease occurrence, development and will aggravate the disease, and some will even produce malignant tumor. In the study of molecular mechanism of inflammation, several signaling pathways have been found. The inflammatory signaling pathway mediated by pattern recognition receptor has played an important role in many diseases. Based on the key molecules in these important inflammatory signaling pathway, the screening of anti-inflammatory drugs has been widely concerned. Panax species is a valuable Chinese herbal medicine, it has very high medicinal value. China ginseng species include: Ginseng, Radix Notoginseng, Rhizoma Panacis Japonici and its variants Rhizoma Panacis Majoris etc. Saponin is one of the main active components of ginseng species, pharmacological researches show that it has good anti-inflammatory effect. In this paper, the recent research achievements of pattern recognition receptor mediated inflammatory signaling pathways and Panax plant saponin anti-inflammatory were summarized to provide the theoretical basis for the study of anti-inflammatory drugs.