Synthesis, DNA binding, and cytotoxicity studies of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates |
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| Authors: | Kamal Ahmed Ramu R Tekumalla Venkatesh Khanna G B Ramesh Barkume Madan S Juvekar Aarti S Zingde Surekha M |
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| Institution: | Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India. ahmedkamal@iict.res.in |
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| Abstract: | A series of pyrrolo2,1-c]1,4]benzodiazepine-anthraquinone conjugates have been prepared and evaluated for their DNA binding ability as well as anticancer activity. Some of these molecules have shown significant anticancer activity in a number of cancer cell lines. |
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