|
|||||
|
|
Lipase-catalyzed remote kinetic resolution of arylic nitriles with adjacent quaternary chiral center and the determination of their absolute configuration |
|
| Authors: | Dai Sig Im Chan Seong Cheong So Ha Lee |
| Institution: | a Life Sciences Division, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, South Korea b Computer-Aided Molecular Design & Bioscience Research Co. Ltd., 464-5, Jung-ri, Kusong-myon, Yongin-shi, Kyonggi-do 449-916, South Korea |
| Abstract: | Enzymatic resolution of tertiary arylic nitrile alcohols (1–8) by lipases from Pseudomonas cepacia (PCL), Pseudomonas flurescens (LAK, made by Amano Enzyme Co. Ltd.), Pseudomonas fluorescens (PFL) and Candida rugosa (CRL) were described, and the absolute configuration of the resolved chiral alcohols (1–8) were determined by chemical transformations to the compounds with known configuration. |
| Keywords: | Lipase Arylic nitrile Resolution Biocatalyst |
| 本文献已被 ScienceDirect 等数据库收录！ | |