| 整合素与肿瘤的转移与血管生成 |
| |
| 引用本文： | 张丽,叶志义.整合素与肿瘤的转移与血管生成[J].现代生物医学进展,2007,7(2):290-292. |
| |
| 作者姓名： | 张丽 叶志义 |
| |
| 作者单位： | 重庆大学生物工程学院,重庆,400044 |
| |
| 基金项目： | 国家自然科学基金;重庆大学校科研和教改项目 |
| |
| 摘 要： | 整合素是一类介导细胞与细胞外基质及细胞与细胞间黏附的细胞黏附分子受体,肿瘤细胞与胞外基质的相互作用对肿瘤的生成及转移有着重要的影响,整合素在肿瘤的生成、侵袭、转移以及肿瘤血管的生成过程中起着重要的作用。本文对整合素的结构、功能,以及它在肿瘤的血管生成过程中的作用,它与细胞外基质间的相互关系做了介绍。
|
| 关 键 词： | 整合素 肿瘤 细胞外基质 血管生成 |
| 文章编号： | 24057892 |
| 修稿时间： | 11 8 2006 12:00AM |
Relationship Between Integrins and Tumor's Metastasis and Angiogenesis |
| |
| ZHANG Li,YE Zhi-yi.Relationship Between Integrins and Tumor's Metastasis and Angiogenesis[J].Progress in Modern Biomedicine,2007,7(2):290-292. |
| |
| Authors: | ZHANG Li YE Zhi-yi |
| |
| Institution: | College of Bioengineering, Chongqing University, ChongQing, 400044, China |
| |
| Abstract: | The integrin family is the important receptor of cellular adhension molecules,which mediates the adhension be- tween cell and cell or cell and cell cxtracellular matrix.The interaction between tumor cells and the ECM strongly influences tumor development,affecting cell proliferation and the survival,as well as the ability to migrate beyond the original location into other tis- sues to form metastasis.Many of these interactions are mediated by integrins.It plays a significant role in tumor devolopment,inva- sion and metastasis.This article reviews the construction and function of integrins,evaluates the role for integrins in tumor angio- genesis,and the relationship between integrins and the extracellular matrix. |
| |
| Keywords: | Integrin Tumor Extracellular matrix Angiogenesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
