Sustained impairment of pituitary and testicular function in prostatic cancer patients treated with a depot form of a GnRH agonist |
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| Authors: | E Rolandi R Franceschini C Giberti T Brancadoro G Martorana T Barreca |
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| Affiliation: | Department of Internal Medicine, University of Genoa, Italy. |
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| Abstract: | Seven patients suffering from prostatic cancer were treated with a slow-release D-Trp-6-LHRH preparation for a period of 24-32 months. LH, FSH, PRL and testosterone levels were evaluated before and at the end of treatment and then 40 days later. Baseline and GnRH-, TRH-, and HCG-stimulated hormonal values decreased after treatment. The possibility that a long-term treatment with GnRH analogues induces a sustained suppression of pituitary and testicular function is suggested. |
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