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Insights into hERG K+ channel structure and function from NMR studies |
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| Authors: | Chai Ann Ng Allan M Torres Guilhem Pagès Philip W Kuchel Jamie I Vandenberg |
| Institution: | 1. Mark Cowley Lidwill Research Programme in Cardiac Electrophysiology, Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, NSW, 2010, Australia 2. School of Molecular Bioscience, University of Sydney, Sydney, NSW, 2006, Australia 5. St Vincent’s Clinical School, University of New South Wales, Darlinghurst, NSW, 2052, Australia 3. School of Biomedical and Health Sciences, University of Western Sydney, Penrith, NSW, 2751, Australia 4. Mechanistic Systems-Biology NMR Group, Singapore Bioimaging Consortium, Biomedical Sciences Institutes, 11 Biopolis Way, #02-02 Helios, Singapore, 138667, Singapore |
| Abstract: | The unique gating kinetics of hERG K+ channels are critical for normal cardiac repolarization, and patients with mutations in hERG have a markedly increased risk of cardiac arrhythmias and sudden cardiac arrest. HERG K+ channels are also remarkably promiscuous with respect to drug binding, which has been a very significant problem for the pharmaceutical industry. Here, we review the progress that has been made in understanding the structure and function of hERG K+ channels with a particular focus on nuclear magnetic resonance studies of the domains of the hERG K+ channel. |
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