Effect of Sub-deficient Zinc Status on Insulin Sensitivity after Burn Injury in Rats |
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Authors: | Richard Claeyssen Maud Andriollo-Sanchez Josiane Arnaud Laurence Touvard Antonia Alonso Yves Chancerelle Anne-Marie Roussel Diane Agay |
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Institution: | (1) Centre de Recherches du Service de Santé des Armées, 24 Avenue des Maquis du Grésivaudan, BP 87, 38702 La Tronche cedex, France;(2) INSERM U884, Laboratoire de Bioénergétique Fondamentale et Appliquée, Université Joseph Fourier, BP 53, 38041 Grenoble cedex 9, France;(3) Département de Biologie Intégrée, CHU Grenoble, BP 217, 38043 Grenoble Cedex 9, France |
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Abstract: | Although zinc status is an important parameter in insulin sensitivity, data concerning its implication in noxious burn-induced
insulin resistance are scarce. The present study was designed to evaluate the impact of zinc status before burn on the recovery
of injury with focus on plasma insulin and glucose levels. The experiment was performed in male adult Wistar rats fed from
weaning with a zinc normal diet (80 ppm) or a depleted zinc diet (10 ppm) for 8 weeks and burned to third degree on 20% of
their total body surface area. Blood and tissue samples were collected 3, 6, and 24 h after injury in order to study biochemical
parameters and the glucose/insulin response in relation with the zinc status. After burn, zinc-depleted rats presented an
exacerbated decrease in plasma zinc level. In addition, the burn-induced insulin resistance, leading to protein catabolism,
was emphasized, with higher plasma insulin, glucose, and leptin levels in zinc-deficient animals versus normal-fed rats. Our
experimental results underlined the interest to early control the zinc status in order to limit the deleterious effects of
oxidative stress and insulin resistance in burned patients. |
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Keywords: | Burn injury Zinc status Insulin sensitivity Hyperglycaemia Rat model |
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