Serum levels of heat shock protein 27 in patients with acute ischemic stroke |
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Authors: | Gabriella Gruden Federica Barutta Irene Catto Giovanni Bosco Maria Giovanna Caprioli Silvia Pinach Paolo Fornengo Paolo Cavallo-Perin Ottavio Davini Paolo Cerrato Graziella Bruno |
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Affiliation: | 1. Department of Medical Science, University of Turin, C/so Dogliotti 14, 10126, Turin, Italy 2. Stroke Unit, San Giovanni Battista Hospital, Turin, Italy 3. Radiology 2 - San Giovanni Battista Hospital, Turin, Italy
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Abstract: | Expression of intracellular heat shock protein 27 (Hsp27) rises in the brain of animal models of cerebral ischemia and stroke. Hsp27 is also released into the circulation and the aim of the present study was to investigated if serum Hsp27 (sHsp27) levels are altered in patients with acute ischemic stroke. sHsp27 was measured in 15 patients with acute ischemic stroke and in 14 control subjects comparable for age, sex, and cardiovascular risk factors. In patients, measurements were performed at admission and 1, 2, and 30 days thereafter. At admission, mean sHsp27 values were threefold higher in patients than in controls. In patients, sHsp27 values dropped after 24 h, rose again at 48 h, and markedly declined at 30 days, indicating the presence of a temporal trend of sHsp27 values following acute ischemic stroke. |
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Keywords: | Acute ischemic stroke Heat shock protein 27 Serum biomarker Stress response |
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