Extra-hippocampal projections of CCK neurons of the hippocampus and subiculum |
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| Authors: | G E Handelmann M C Beinfeld T L O'Donohue J B Nelson D E Brenneman |
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| Institution: | 1. Lab. Clinical Science, NIMH, Bethesda, MD 20205 USA;2. Department of Pharmacology, St. Louis University, St. Louis, MO 63104 USA;3. Unit on Neuroendocrinology, NINCDS-ETB, Bethesda, MD 20205 USA;4. Lab. Developmental Neurobiology, NICHD, Bethesda, MD 20205 USA |
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| Abstract: | A population of neurons in the hippocampus and subiculum contains cholecystokinin (CCK). Following transection of the dorsal fornix, a major afferent pathway of the hippocampus and associated structures. CCK levels were reduced in the septum and hypothalamus. A microdissection analysis indicated that the loss of CCK occurred in nuclei receiving direct projections from the hippocampus and subiculum, suggesting that CCK-containing neurons in the hippocampus and subiculum project to extrahippocampal regions. |
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| Keywords: | Cholecystokinin Fornix Hippocampus Subiculum |
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