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Evolutionary dynamics of eukaryotic selenoproteomes: large selenoproteomes may associate with aquatic life and small with terrestrial life |
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| Authors: | Alexey V Lobanov Dmitri E Fomenko Yan Zhang Aniruddha Sengupta Dolph L Hatfield Vadim N Gladyshev |
| Affiliation: | (1) Department of Biochemistry, University of Nebraska, Lincoln, NE 68588, USA;(2) Section on the Molecular Biology of Selenium, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA |
| Abstract: | BackgroundSelenocysteine (Sec) is a selenium-containing amino acid that is co-translationally inserted into nascent polypeptides by recoding UGA codons. Selenoproteins occur in both eukaryotes and prokaryotes, but the selenoprotein content of organisms (selenoproteome) is highly variable and some organisms do not utilize Sec at all. |
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