NCD3G: a novel nine-cysteine domain in family 3 GPCRs |
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| Authors: | Liu Xianghua He Quanyuan Studholme David J Wu Qi Liang Songping Yu Long |
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| Institution: | State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Handan Road 220, Shanghai 200433, P.R. China. |
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| Abstract: | The NCD3G for nine-cysteine domain of family 3 G-protein-coupled receptors (GPCRs)] domain is a novel protein domain that is conserved in family 3 GPCRs, including metabotropic glutamate receptors, calcium-sensing receptors, pheromone receptors and taste receptors, with the exception of GABA(B) receptors. The NCD3G domain contains nine highly conserved cysteine residues. Structural predictions suggest that NCD3G might possess four beta strands and three disulfide bridges. The structural model of NCD3G highlights the conserved residues co-segregated with certain familial diseases. |
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