Proteome sequence features carry signatures of the environmental niche of prokaryotes |
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| Authors: | Zlatko Smole Nela Nikolic Fran Supek Tomislav ?muc Ivo F Sbalzarini and Anita Krisko |
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| Institution: | (1) Institute for Cell Biology, ETH Zuerich, Schafmattstrase 18, 8093 Zuerich, Switzerland;(2) Mediterranean Institute for Life Sciences, Mestrovicevo setaliste bb, 21000 Split, Croatia;(3) Institute of Biogeochemistry and Pollutant Dynamics, ETH Zuerich, Unversit?tstrasse 16, 8092 Zuerich, Switzerland;(4) Division of Electronics, Rudjer Boskovic Institute, Bijenicka 54, 10000 Zagreb, Croatia;(5) Institute of Theoretical Computer Science and Swiss Institute of Bioinformatics, ETH Zurich, Zurich, Switzerland;(6) Institut National de la Sant? et de la Recherche M?dicale U1001, Universit? Paris Descartes, Facult? de M?decine, 156 rue de Vaugirard, 75730 Paris Cedex 15, France |
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| Abstract: | Background Prokaryotic environmental adaptations occur at different levels within cells to ensure the preservation of genome integrity,
proper protein folding and function as well as membrane fluidity. Although specific composition and structure of cellular
components suitable for the variety of extreme conditions has already been postulated, a systematic study describing such
adaptations has not yet been performed. We therefore explored whether the environmental niche of a prokaryote could be deduced
from the sequence of its proteome. Finally, we aimed at finding the precise differences between proteome sequences of prokaryotes
from different environments. |
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