Persistence of decidual NK cells and KIR genotypes in healthy pregnant and preeclamptic women: a case-control study in the third trimester of gestation |
| |
| Authors: | Elly N Sánchez-Rodríguez Sonia Nava-Salazar C Adriana Mendoza-Rodríguez Carlos Moran Juan F Romero-Arauz Enrique Ortega Julio Granados Alicia Cervantes-Peredo Marco Cerbón |
| |
| Affiliation: | 1.Departamento de Biología,Facultad de Química, Universidad Nacional Autónoma de México. Ciudad Universitaria,Coyoacán,México;2.Servicio de Complicaciones Hipertensivas,,UMAE de Ginecología y Obstetricia "Luis Castelazo Ayala", Instituto Mexicano del Seguro Social,México;3.Departamento de Inmunología,,Instituto de Investigaciones Biomédicas,UNAM,México;4.Departamento de Transplantes,,Instituto Nacional de Ciencias Médicas y de la Nutrición "Salvador Zubirán",México;5.Servicio de Genética,Hospital General de México/Facultad de Medicina,,UNAM,México |
| |
| Abstract: | Background Natural Killer (NK) cells are the most abundant lymphocytes in the decidua during early gestation. The interactions of NK cells with the extravillous cytotrophoblast have been associated with a normal spiral artery remodeling process, an essential event for a successful pregnancy. Recent data indicate that alterations in the amount of decidual NK (dNK) cells contribute to the development of preeclampsia (PE). Moreover, genetic studies suggest that Killer Immunoglobulin-like Receptors (KIR) expressed in dNK cells influence the susceptibility to PE. Although dNK cells have been well characterized during early pregnancy, they have been scarcely studied in the third trimester of gestation. The aim of this work was to characterize dNK cells at the last trimester of gestation and to analyze the KIR genotype of healthy and PE women. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
