Cytoskeletal remodelling proteins identified in fetal-maternal interface in pregnant women and rhesus monkeys |
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Authors: | Email author" target="_blank">Sarah?PauleEmail author Ying?Li Guiying?Nie |
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Institution: | (1) Prince Henry’s Institute of Medical Research, PO Box 5152, Clayton, VIC, 3168, Australia |
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Abstract: | The uterus undergoes dramatic remodelling in preparation for embryo implantation and pregnancy establishment. A receptive
uterus is pivotal for embryo attachment, implantation and the eventual formation of a hemochorial placenta. We have previously
identified by proteomics that tropomyosin alpha-4 chain (TPM4), protein disulfide isomerase A1 (PDIA1) and src substrate cortactin
8 (SRC8) were up regulated in the decidualized stromal cells during the late secretory phase of the menstrual cycle in women.
These three proteins are associated with cytoskeletal remodelling. This study determined the localization of these three cytoskeletal
proteins in the fetal-maternal interface including the decidual cells in the 1st trimester of pregnancy in women and rhesus
monkeys. Immunohistochemical analysis revealed that TPM4, PDIA1 and SRC8 were all expressed by the decidual cells and the
wall of the spiral arterioles in pregnant women. Similar expression pattern were also found in the rhesus monkey. In addition,
TPM4, PDIA and SRC8 were also localized to the trophoblast cells, further highlighting the importance of these cytoskeletal
remodelling proteins in early pregnancy. |
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Keywords: | |
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