Occurrence of multipolar mitoses and association with Aurora-A/-B kinases and p53 mutations in aneuploid esophageal carcinoma cells |
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| Authors: | Christiane D Fichter Corinna Herz Claudia Münch Oliver G Opitz Martin Werner Silke Lassmann |
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| Institution: | (1) Institute of Pathology, University Medical Center, Freiburg, Germany;(2) Tumorzentrum Ludwig Heilmeyer - Comprehensive Cancer Center, University Medical Center, Freiburg, Germany;(3) Dept. of Environmental Health Sciences, University Medical Center Freiburg, Freiburg, Germany |
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| Abstract: | Background Aurora kinases and loss of p53 function are implicated in the carcinogenesis of aneuploid esophageal cancers. Their association
with occurrence of multipolar mitoses in the two main histotypes of aneuploid esophageal squamous cell carcinoma (ESCC) and
Barrett's adenocarcinoma (BAC) remains unclear. Here, we investigated the occurrence of multipolar mitoses, Aurora-A/-B gene
copy numbers and expression/activation as well as p53 alterations in aneuploid ESCC and BAC cancer cell lines. |
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