| C端截短突变体mCCL21-a(1-57)可拮抗CCL21介导的ERK磷酸化及细胞迁移 |
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| 引用本文： | 张淑,张革,王红胜,张帆,谭毅,马伟峰,杜军. C端截短突变体mCCL21-a(1-57)可拮抗CCL21介导的ERK磷酸化及细胞迁移[J]. 中国生物化学与分子生物学报, 2011, 0(2): 161-167 |
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| 作者姓名： | 张淑 张革 王红胜 张帆 谭毅 马伟峰 杜军 |
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| 作者单位： | 中山大学药学院;温州医学院中美糖尿病并发症研究所;南方医科大学公共卫生与热带医学学院; |
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| 基金项目： | 国家自然科学基金项目(No.30600768,No.81071712,No.4103059); 广东省科技计划(No.2007B030704007); 广东省医学科研基金(No.B2009139)~~ |
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| 摘 要： | 趋化因子CCL21(CC-chemokine ligand 21,CCL21)与其受体CCR7(CC-chemokine receptor 7,CCR7)的结合可以促进肿瘤的侵袭和转移.本研究旨在构建人趋化因子CCL21的截短突变体,竞争性抑制CCL21与CCR7的结合,从而抑制肿瘤的转移.本研究构建了CCL21的10...
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| 关 键 词： | 次级淋巴组织趋化因子(SLC/CCL21) CC类趋化因子受体CCR7 拮抗剂 肿瘤转移 |
| 收稿时间： | 2010-11-15 |
mCCL21-a (1-57),a C-terminal Deletion Mutant of CCL21,Inhibits CCL21-mediated Migration in Cultured SW480 Cells by Suppressing ERK Activation |
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| ZHANG Shu),ZHANG Ge),WANG Hong-Sheng),ZHANG Fan),TAN Yi),MA Wei-Feng),DU Jun) School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou ,China,) Chinese-American Research Institute for Diabetic Complications,Wenzhou Medical College,Wenzhou ,) School of Public Health , Tropical Medicine,Southern Medical University,Guangzhou ,China). mCCL21-a (1-57),a C-terminal Deletion Mutant of CCL21,Inhibits CCL21-mediated Migration in Cultured SW480 Cells by Suppressing ERK Activation[J]. Chinese Journal of Biochemistry and Molecular Biology, 2011, 0(2): 161-167 |
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| Authors: | ZHANG Shu) ZHANG Ge) WANG Hong-Sheng) ZHANG Fan) TAN Yi) MA Wei-Feng) DU Jun) School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou China ) Chinese-American Research Institute for Diabetic Complications Wenzhou Medical College Wenzhou ) School of Public Health Tropical Medicine Southern Medical University Guangzhou China) |
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| Affiliation: | ZHANG Shu1),ZHANG Ge1),WANG Hong-Sheng1),ZHANG Fan1),TAN Yi2),MA Wei-Feng3),DU Jun1)*(1) School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China,2) Chinese-American Research Institute for Diabetic Complications,Wenzhou Medical College,Wenzhou 325035,3) School of Public Health and Tropical Medicine,Southern Medical University,Guangzhou 510515,China) |
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| Abstract: | The migration of tumor cells into the lymph nodes is an important aspect of cancer.CC-chemokine receptor 7(CCR7) has been shown to play an important role in tumor cell migration and lymph node metastasis.In our study,ten truncated mutants of CC-chemokine ligand 21(CCL21) were constructed.mCCL21-a(1-57),a novel C-terminal deletion mutant of human CCL21,exhibited favorable antagonistic effect on CCL21-stimulated chemotaxis of human colorectal carcinoma cell line SW480 in the pre-screening assays.Prokaryotic e... |
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| Keywords: | CCL21 CCR7 antagonist tumor metastasis |
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