| MEK1-ERKs级联激活方式是调控单纯疱疹病毒Ⅱ型复制的重要机制 |
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| 引用本文： | 易婷,张浩,彭宜红,朱萌,何晓燕,黄孝天. MEK1-ERKs级联激活方式是调控单纯疱疹病毒Ⅱ型复制的重要机制[J]. 中国生物化学与分子生物学报, 2011, 0(2): 142-147 |
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| 作者姓名： | 易婷 张浩 彭宜红 朱萌 何晓燕 黄孝天 |
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| 作者单位： | 北京大学医学部病原生物学系;南昌大学医学院微生物学教研室;北京大学天然药物及仿生药物国家重点实验室; |
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| 基金项目： | 国家高技术研究发展项目(863计划,No.2007AA02Z317)~~ |
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| 摘 要： | 本研究通过阐明MEK1和MEK2亚型在单纯疱疹病毒Ⅱ型(herpes simplex virus type 2,HSV2)复制中介导的Raf/MEK/ERK(简称ERK)通路活化中的作用,以期进一步阐明该通路调控病毒复制的机制.研究中应用了MEK抑制剂U0126、针对MEK1和MEK2的特异性小干扰RNA(small ...
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| 关 键 词： | 细胞外信号调节激酶通路 MEK1 MEK2 单纯疱疹病毒Ⅱ型 小干扰RNA |
| 收稿时间： | 2010-11-26 |
Activation of MEK1-ERKs is Essential for Herpes Simplex Virus Type 2(HSV2) Replication |
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| YI Ting ),),ZHANG Hao),),PENG Yi-Hong),),ZHU Meng),HE Xiao-Yan),HUANG Xiao-Tian). Activation of MEK1-ERKs is Essential for Herpes Simplex Virus Type 2(HSV2) Replication[J]. Chinese Journal of Biochemistry and Molecular Biology, 2011, 0(2): 142-147 |
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| Authors: | YI Ting ) ) ZHANG Hao) ) PENG Yi-Hong) ) ZHU Meng) HE Xiao-Yan) HUANG Xiao-Tian) |
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| Affiliation: | YI Ting 1),2),ZHANG Hao1),3),PENG Yi-Hong1),3)*,ZHU Meng1),HE Xiao-Yan1),HUANG Xiao-Tian2) *(1) Department of Microbiology,Peking University Health Science Center,Beijing 100191,China,2) Department of Medical Microbiology,Medical School of Nanchang University,Nanchang 330006,3) State Key Laboratory of Natural and Biomimetic Drugs,Peking University,China) |
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| Abstract: | Raf /MEK /ERK signaling pathway(ERK pathway) is required for amplification of many viruses.MEK1 and MEK2 are two kinase isoforms that operate immediately upstream of ERK,relaying signals from Raf by phosphorylating ERK.Herpes simplex virus type2(HSV2) infection causes activation of both MEK1 and MEK2,but only MEK1 is required for virus amplification.However,the mechanismsunderlying the distinct functions of MEK subtypes during the course of HSV2 replication remain largely unknown.In the present study,a biph... |
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| Keywords: | extracellular signal regulated kinase pathway MEK1 MEK2 herpes simplex virus type 2 small interfering RNA |
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