| 共振喇曼光谱技术在恶性肿瘤诊断中的应用 |
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| 引用本文： | 于德泉,何中秋,赵岩.共振喇曼光谱技术在恶性肿瘤诊断中的应用[J].现代生物医学进展,2011,11(2):287-288. |
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| 作者姓名： | 于德泉 何中秋 赵岩 |
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| 作者单位： | 1. 辽宁省肿瘤研究所,辽宁,沈阳,110042
2. 辽宁省肿瘤医院胃外科,辽宁,沈阳,110042 |
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| 摘 要： | 目的:探讨共振喇曼光谱技术用于早期恶性肿瘤诊断的研究。方法:利用氩离子激光作为线偏振光的特点,采集偏振荧光光谱,对荧光光谱的偏振态进行分析。利用不同荧光物质的荧光可能具有不同偏振态的特点减少其它荧光物质的荧光对光谱分析的影响。血清样品产生的荧光也具有确定的偏振性。对所检测病人血清经激光分析仪进行喇曼光谱技术分析,光谱数据经计算机软件处理,自动显示图谱和数据,并直接给出各项指标及诊断提示。本结果与细胞病理学结果进行了对照研究。结果:恶性肿瘤样本176例,检测出阳性病例141例,阳性符合率为80.1%;良性肿瘤样本52例,4例阳性,假阳性率为7.7%;正常体检样本248例,检测结果均为阴性。结论:喇曼光谱技术适用于肿瘤初筛、普查及早期诊断,有推广应用前途。
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| 关 键 词： | 喇曼光谱 恶性肿瘤 自体荧光 |
Application of Ultraviolet Resonance Raman Spectroscopy in Diagnosis
of Human Malignancies |
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| YU De-quan,HE Zhong-qiu,ZHAO Yan.Application of Ultraviolet Resonance Raman Spectroscopy in Diagnosis
of Human Malignancies[J].Progress in Modern Biomedicine,2011,11(2):287-288. |
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| Authors: | YU De-quan HE Zhong-qiu ZHAO Yan |
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| Institution: | 1 Liaoning Cancer Institute,Department for Clinical Research,Liaoning Shenyang,110042,China; 2 Liaoning Cancer Hospital,Department of Surgery,liaoning Shenyang,110042,China) |
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| Abstract: | Objective:To investigate the resonance Raman spectroscopy for early diagnosis of malignant tumors.Method:Using the characteristics of argon ion laser as linearly polarized light,polarized fluorescence spectra were collected,and the fluorescence polar-ization spectrum were analyzed.The features of different fluorescent substances having different polarization were utilized to reduce the impact of other fluorescent material on the spectrum.The serum samples also have authentic fluorescence polarization.Raman ... |
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| Keywords: | Raman spectroscopy malignancies autofluorescence |
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