Antifungal effect and action mechanism of antimicrobial peptide polybia‐CP |
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| Authors: | Kairong Wang Fengjing Jia Wen Dang Yanyan Zhao Ranran Zhu Mengyang Sun Shuai Qiu Xiaoping An Zelin Ma Yuanyuan Zhu Jiexi Yan Ziqing Kong Wenjin Yan Rui Wang |
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| Affiliation: | 1. Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, China;2. Institute of Food Safety, State Key Laboratory Base of Food Quality and Safety, Ministry of Science and Technology, Jiangsu Academy of Agricultural Sciences, Nanjing, China |
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| Abstract: | The incidence of life‐threatening invasive fungal infections increased significantly in recent years. However, the antifungal therapeutic options are very limited. Antimicrobial peptides are a class of potential lead chemical for the development of novel antifungal agents. Antimicrobial peptide polybia‐CP was purified from the venom of the social wasp Polybia paulista. In this study, we synthesized polybia‐CP and determined its antifungal effects against a series of Candidian species. Our results showed that polybia‐CP has potent antifungal activity and fungicidal activity against the tested fungal cells with a proposed membrane‐active action mode. In addition, polybia‐CP could induce the increase of cellular reactive oxygen species production, which would attribute to its antifungal activity. In conclusion, the present study suggests that polybia‐CP has potential as an antifungal agent or may offer a new strategy for antifungal therapeutic option. Copyright © 2015 European Peptide Society and John Wiley & Sons, Ltd. |
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| Keywords: | antimicrobial peptide polybia‐CP candidiasis antifungal ROS production |
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