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Novel bioreduction system for the production of chiral alcohols |
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| Authors: | Kataoka M Kita K Wada M Yasohara Y Hasegawa J Shimizu S |
| Affiliation: | (1) Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo-ku, 606-8502 Kyoto, Japan;(2) Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Uji, 611-0011 Kyoto, Japan;(3) Department of Bioscience, Fukui Prefectural University, 4-1-1 Kenjyojima, Matsuoka-cho, 910-1195 Fukui, Japan;(4) Fine Chemical Research Laboratories, Kaneka Corporation, 1-8 Miyamae, Takasago, Hyogo 676-8688, Japan |
| Abstract: | Chiral alcohols are useful intermediates for many pharmaceuticals and chemicals. Enzymatic asymmetric reduction of prochiral carbonyl compounds is a promising method for producing chiral alcohols. There have been many attempts to construct bioreduction systems for the industrial production of chiral alcohols. This review focuses on the establishment of a novel bioreduction system using an Escherichia coli transformant co-expressing genes for carbonyl reductase and cofactor-regeneration enzyme. This bioreduction system could be useful as an all-purpose catalyst for asymmetric reduction reactions. |
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