Glucose regulates its own transport in Ehrlich ascites tumour cells |
| |
Authors: | K P Fung Y M Choy T W Chan W P Lam C Y Lee |
| |
Institution: | 1. Department of Colorectal Surgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China;2. The First School of Clinical Medicine, Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China;3. Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210029, Jiangsu, China |
| |
Abstract: | The capacity of Ehrlich ascites tumour cells to take up 2-deoxy-D-glucose and to bind cytochalasin B varies adaptatively with the level of glucose in the plasma or culture medium. The effect of glucose is exerted directly on the cells and does not necessarily require the participation of hormones such as insulin, glucagon or corticosterone, although glucagon and the glucocorticoids, but not insulin, can also increase the number of glucose carrier molecules administered in vitro. Cycloheximide suppresses the acute inductive effect of glucose, suggesting that protein synthesis might be required for the increased transport activity. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|