Apoptosis extent increases in hybridoma cultures with temperature |
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| Authors: | Nagarathnamma M.M. Rajan G.K. Sureshkumar |
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| Affiliation: | (1) Cell Science, National Centre, Ganeshkind Road, Pune, India;(2) Biochemical Engineering Group, Dept. of Chemical Engineering, Indian Institute of Technology, Bombay, Powai Mumbai, India |
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| Abstract: | Apoptosis plays an important role in determining efficacies of bioreactors employing hybridoma cells. Exposure to a 42°C shock for 1 h increased the apoptosis extent (DNA fragmentation) by 32% in CC9C10 hybridoma. Further, glutamine at 2 mM decreased temperature-induced apoptosis by about 20%. |
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