ELEVATED PLASMA PHENYLALANINE CONCENTRATION AND LYSINE INCORPORATION INTO RIBOSOMAL PROTEIN OF DEVELOPING BRAIN |
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| Authors: | K F Swaiman W B Hosfield B Lemieux |
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| Institution: | Departments of Neurology and Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455 |
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| Abstract: | Hyperphenylalaninemia was induced in 7-day-old rabbits over a 6-hr period by intraperitoneal injection of phenylalanine. l -U-14C]Lysine was injected intraperitoneally into these rabbits and into a control group. The rate of incorporation of l -U-14C]lysme into brain ribosomal protein was decreased during a 5-hr period in the presence of elevated plasma phenylalanine concentrations. Lysine transport from the peritoneum to the plasma was unaffected by the high plasma phenylalanine concentrations. |
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