Tumour invasion: effects of cell adhesion and motility |
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| Authors: | Van Roy F Mareel M |
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| Institution: | Laboratory of Molecular Biology, University of Ghent, Ledeganckstraat 35, B-9000 Ghent, Belgium. |
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| Abstract: | Metastasis is the major cause of failure in cancer therapy. Recent studies of the molecular cell biology of the metastatic process have provided new insights into the mechanisms of cell-cell adhesion, cell-substrate adhesion and cell motility that underly invasion by tumour cells. In this review, Van Roy and Mareel discuss the role of proteins with invasion-promoting and invasion-suppressing functions in metastasis. |
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