Replacement of L-T4 suppository in MMI treated rabbits |
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Authors: | M Yamamoto K Yonezawa M Mizugaki H Toda H Kikuchi T Sakurada S Saito K Yoshinaga |
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Institution: | Hospital of East Japan Railway Company, Miyagi. |
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Abstract: | L-T4 suppositories containing 50, 100 or 200 micrograms of L-T4 were given to rabbits treated with MMI. The serum T4 gradually increased within 3.5 and 6.5 hours following the use of 100 and 200 micrograms of L-T4 suppositories, respectively, without an acute increase in serum T3. The increase in serum T4 continued up to 48 hours. The area under the curve (AUC) for serum T4 was evidently dose-dependent. It is concluded from these results that the T4 suppository will be useful as a replacement therapy for patients with hypothyroidism. |
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