Bradykinin receptors in intestinal smooth muscles and their post-receptor events related to calcium |
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| Authors: | Oztürk Y Altan V M Yıdızoğlu-Arı N Altınkurt O |
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| Affiliation: | 1. Department of Pharmacology, Faculty of Pharmacy, Anadolu University, Eskieşhir, 26470, Turkey.;2. Department of Pharmacology, Faculty of Pharmacy, Ankara University, Ankara, 06100, Turkey, |
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| Abstract: | The effects of trifluoperazine and verapamil on bradykinin- and des-Arg(9)-bradykinin induced responses of isolated rat duodenum and guinea-pig ileum were investigated to elucidate post-bradykinin receptor events. Verapamil and trifluoperazine inhibited bradykinin induced relaxations and contractions and des-Arg(9)- bradykinin induced contractions in rat duodenum. Bradykinin induced contractions of ileum were also inhibited by trifluoperazine and. verapamil. Since non-competitive affinity constants of trifluoperazine and verapamil for the relaxant responses to bradykinin in duodenum and for the contractile responses to bradykinin in ileum are different, post-bradykinin receptor events related to calcium may be different in ileum and duodenum. In addition, affinity constants of bradykinin in guinea-pig ileum and rat duodenum are also disparate suggesting the presence of different types of bradykinin B(2) receptors in these two organs. |
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