Effects of anti-inflammatory drugs on fever and neutrophilia induced by Clostridium difficile toxin B |
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| Authors: | Cardoso R A Filho A A Melo M C Lyerly D M Wilkins T D Lima A A Ribeiro R A Souza G E |
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| Institution: | 1. Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, USP Campus-14040-903, Ribeirão Preto, S.P., Brazil.;2. Department of Physiology and Pharmacology and Division of
Infectious Diseases, Clinical Research Unit, Federal University of Ceará Fortaleza, C.E., Brazil.;3. Department of Anaerobic Microbiology, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA, |
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| Abstract: | This study investigated the ability of Clostridium difficile toxin B, isolated from the VPI 10463 strain, to induce fever and neutrophilia in rats. Intravenous injection of toxin B (0.005-0.5 mug/kg) evoked a dose-dependent increase in body temperature. The febrile response to 0.5 mug/kg of the toxin started in 2.5 h, peaked at 5 h, and subsided fully within 24 h. Toxin B also induced a dosedependent neutrophilia. Pretreatment with indomethacin (2 mg/kg, i.p.) did not affect the neutrophilia induced by toxin B, but significantly reduced the febrile response measured 4 to 8 h after toxin B injection. Dexamethasone (0.5 mg/ kg) also markedly diminished the febrile response induced by toxin B. These results show that Clostridium difficile toxin B induced a febrile response susceptible to inhibition by dexamethasone and indomethacin. Furthermore, they suggest that prostaglandins are not involved in the neutrophilia caused by this toxin. |
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