Interleukin-7 receptor-α gene polymorphisms in bone marrow transplant recipients |
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Authors: | Negar Azarpira Mehdi Dehghani Mahdokth H Aghdaie Masumeh Darai |
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Institution: | (1) Organ Transplant Research Center, Shiraz University of Medical Sciences, Zand Street, Nemazi Hospital, 7193711351 Shiraz, Iran;(2) Bone Marrow Transplant, Shiraz University of Medical Sciences, Shiraz, Iran |
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Abstract: | Graft-versus-host disease is the main complication after hematopoietic stem cells transplantation (HSCT). Non-HLA genotypes,
such as cytokines, have been investigated for their potential roles in the occurrence and severity of GVHD as well as for
their contribution to overall transplant-related mortality and survival. IL-7 which is secreted by bone marrow stromal cells
plays an important role in the development and survival of T cells. Its effect is mediated via interleukin 7 receptor (IL7R).
This study investigates the possible links between IL-7αR single nucleotide polymorphisms (+510 C/T, +1237 A/G, +2087 T/C
and +3110A/G) and transplant outcomes among 116 recipients of HSCT. Genotypes were determined using polymerase chain reaction—sequence-specific
primers. No significant differences were observed between the genotypic distributions of IL-7αR polymorphisms and incidence
of acute or chronic graft versus host disease. Additional studies with larger sample are necessary to further define the influence
of IL-7αR on the immune response after bone marrow transplantation. |
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