Putative dengue virus receptors from mosquito cells |
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Authors: | Mara de Lourdes Muñoza Alejandro Cisnerosa Jorge Cruza Pradeep Dasa Rosalinda Tovara Arturo Ortegaa |
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Institution: | Departamento de Genética y Biologı́a Molecular, CINVESTAV-IPN, Apartado Postal 14-740, México D.F. 07000, Mexico |
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Abstract: | Dengue viruses are arthropod-borne, single-stranded RNA viruses. Aëdes aegypti and Aëdes albopictus are the principal vectors. In order to understand the molecular basis of dengue virus infections we explored the biochemical identity of dengue-2 (DEN-2) virus receptors in the Aëdes albopictus-derived cell line C6/36. We show here that DEN-2 interacts with two major polypeptides of 80 and 67 kDa. Polyclonal anti-C6/36 membrane antibodies block DEN-2 binding to intact C6/36 monolayers as well as to membrane extracts. Our results strongly suggest that the identified polypeptides are part of the DEN-2 receptors. |
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Keywords: | Dengue virus Receptor C6/36 cell |
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