Effect of cyclo- and lipoxygenase blockade on the development of immunogenic shock

In acute experiments on anesthetized dogs it was shown that simultaneous blockade of cyclo- and lipoxygenase (indomethacin and quercetin) completely prevented the development of hypotensive reaction after immune influence induced by intracoronary injection of anti-cardiac antibodies. The prevention of the development of shock reaction was caused by complete depression of pooling blood reaction in the periphery of the vascular bed with the following limitation of venous return to the heart and sharp drop in the cardiac output. Thus, metabolites of arachidonic acid dilating venous part of the vascular bed are of great importance for the development of immunogenic shock.