Cell Physician: Reading Cell Motion |
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Authors: | Hasan Coskun Huseyin Coskun |
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Institution: | (1) Department of Mathematics, Texas A&M University-Commerce, Commerce, TX, USA;(2) Department of Mathematics, Ohio State University, Columbus, OH, USA;(3) Mathematical Bioscience Institute, Ohio State University, Columbus, OH, USA |
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Abstract: | Cell motility is an essential phenomenon in almost all living organisms. It is natural to think that behavioral or shape changes
of a cell bear information about the underlying mechanisms that generate these changes. Reading cell motion, namely, understanding
the underlying biophysical and mechanochemical processes, is of paramount importance. The mathematical model developed in
this paper determines some physical features and material properties of the cells locally through analysis of live cell image
sequences and uses this information to make further inferences about the molecular structures, dynamics, and processes within
the cells, such as the actin network, microdomains, chemotaxis, adhesion, and retrograde flow. The generality of the principals
used in formation of the model ensures its wide applicability to different phenomena at various levels. Based on the model
outcomes, we hypothesize a novel biological model for collective biomechanical and molecular mechanism of cell motion. |
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