Investigations into the direct effects of insulin on hepatic ketogenesis, lipoprotein secretion and pyruvate dehydrogenase activity |
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Authors: | M E Laker P A Mayes |
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Abstract: | In the rat liver perfused with whole rat blood containing either decreased or increased concentrations of non-esterified fatty acids, insulin decreased production of acetoacetate and 3-hydroxybutyrate and stimulated secretion of very-low-density-lipoprotein triacylglycerol. In these same livers, pyruvate dehydrogenase activity was not altered by insulin addition, although it was diminished by non-esterified fatty acids. |
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