Alternative Forms of Interaction of Substance P and Opioids in Nociceptive Transmission |
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Authors: | Maszczynska Iwona Lipkowski Andrzej W Carr Daniel B Kream Richard M |
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Institution: | (1) Neuropeptide Laboratory, Medical Research Centre, Polish Academy of Sciences, Dworkowa Street 3, PL-00-784 Warsaw, Poland;(2) Anesthesia Research Laboratory, New England Medical Center and Tufts University School of Medicine, 750 Washington Street, (Box 298), 02114 Boston, MA, U.S.A. |
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Abstract: | Summary Many years preclinical and clinical anatomic, pharmacologic, and physiologic studies suggest that SP- and opioid-expressing
neurons produce opposite biological effects at the spinal level, i.e., nociception and antinociception, respectively. However,
in certain circumstances intrathecally administered SP is capable of reinforcing of spinal morphine analgesia and may therefore
function as an opioid adjuvantin vivo. The SP dose-response curve of spinally administered SP follows a bell-shaped or inverted-U configuration, permitting pharmacological
dissociation of opioid-potentiating and analgesic properties of SP from traditional hyperalgesic effects seen at significantly
higher concentrations. This analgesic effect is blocked by naloxone but unaffected by transection of the spinal cord, thus
demonstrating the lack of supraspinal modulation. The present report briefly describes both reinforcing and opposing interactions
between multiple opioid systems and substance P at the spinal level. We propose that a likely mechanism underlying SP-mediated
enhancement of opioid analgesia is the ability of SP to release endogenous opioid peptides within the local spinal cord environment. |
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Keywords: | antinociception interactions between opioids and substance P opioids substance P |
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