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| 精神分裂症易感基因GULP1与中国人群大脑容量的相关性研究 | |
| 引用本文： | 施晓东,王金凯,李易,罗雄剑,张卫,宿兵.精神分裂症易感基因GULP1与中国人群大脑容量的相关性研究[J].动物学研究,2009,30(4):377-380. |
| 作者姓名： | 施晓东 王金凯 李易 罗雄剑 张卫 宿兵 |
| 作者单位： | 1. 曲靖师范学院,生物资源与环境科学学院,曲靖,655011 2. 中国科学院昆明动物研究所,遗传资源与进化国家重点实验室,昆明,650223;中国科学院昆明灵长类研究中心,昆明,650223;中国科学院研究生院,北京,100049 3. 中国科学院昆明动物研究所,遗传资源与进化国家重点实验室,昆明,650223;中国科学院昆明灵长类研究中心,昆明,650223 |
| 基金项目： | 云南省科技计划项目(2006C0083M) |
| 摘 要： | 精神分裂症是一种复杂的精神疾病，全世界约有1%的人患有这种疾病。以往的研究发现精神分裂症患者的脑容量比正常人小，且一些精神分裂症易感的DNA序列多态性也同时与脑的结构异常有关，这与精神分裂症的神经发育假说是吻合的。最近研究发现人的GULP1基因的两个SNP（rs2004888和rs4522565）与精神分裂症显著相关。为了研究这两个精神分裂症易感的SNP是否也符合神经发育假说，我们检测了791个正常人的这两个SNP的基因型并测量它们的脑容量，相关性分析发现这两个SNP和脑容量无关，说明GULP1的精神分裂症易感性存在更加复杂的机制。 |
| 关 键 词： | 精神分裂症 脑容量 GULP1 SNP |
| 收稿时间： | 2009-6-18 |
Association Study of a Schizophrenia Susceptible Gene GULP1 with Brain Volume in Chinese Populations |
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| SHI Xiao-dong,WANG Jin-kai,LI Yi,LUO Xiong-jian,ZHANG Wei,SU Bing.Association Study of a Schizophrenia Susceptible Gene GULP1 with Brain Volume in Chinese Populations[J].Zoological Research,2009,30(4):377-380. | |
| Authors: | SHI Xiao-dong WANG Jin-kai LI Yi LUO Xiong-jian ZHANG Wei SU Bing |
| Institution: | 1. College of Biological Resources and Environmental Science, Qujing Normal University, Qujing 655011, China; 2. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China; 3. Kunming Primate Research Centre, the Chinese Academy of Sciences, Kunming 650223, China; 4, Graduate University of the Chinese Academy of Sciences, Beijing 100049, China |
| Abstract: | Schizophrenia is a complex mental disease which affects about 1% of the world population. Previous studies reported that the brain volumes of the schizophrenia patients were much smaller than normal people and many schizophrenia susceptible genetic variants were associated with structural brain abnormalities in patients, which is consistent with the neurodevelopmental hypothesis of the etiology of schizophrenia. Recently, two SNPs (rs2004888 and rs452256) of GULP1 were found to be significantly associated w... |
| Keywords: | Schizophrenia Brain volume GULP1 SNP |
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