Genetic aspects of arterial hypertension: the role of Y chromosome and mitochondrial DNA |
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Authors: | Monastyrskaia E A Murashev A N Khokhlova O N Saprunova V B Korshunov V A Koshelev V B |
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Institution: | Moscow State University, Russia. |
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Abstract: | A study on hybrids from reciprocal crossing of the SHR-SP and the WKY has shown that Y-chromosome and mitochondrial DNA the affect development of the spontaneous hypertension. The Y-chromosome takes part in disorders of baroreceptive sensitivity in phenylnephrine assay associated with hypertension. Although our findings suggest that structural remodelling of peripheral vascular resistance and an increase in noradrenaline-dependent vasocostriction is genetically determined in hypertensive rats, we could not corroborate the role of the Y-chromosome and mitochondrial DNA in the process. A difference was shown between male and female SHR-SP in the level of arterial pressure and in development of the vascular structure changes. |
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