Cytosolic insulin-binding proteins of mouse liver cells |
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Authors: | Lokhov Petr G Moshkovskii Sergei A Ipatova Olga M Prozorovskii Vladimir N |
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Institution: | Institute of Biomedical Chemistry, 119121 Pogodinskaya st 10, Moscow, Russia. proteomics@ibmh.msk.su |
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Abstract: | It has been recently shown that insulin retains its biological activity after receptor-directed internalization and it may affect the cell metabolism by interaction with cytosolic insulin-binding proteins (CIBPs). Using affinity chromatography combined with SDS-PAGE and MALDI-TOF mass-spectrometry we have identified 7 proteins from mouse liver cells that specifically bind to the insulin, including adenylate kinase 2 (25.6 kD), kinesin superfamily protein 20B (26.0 kD), hepatic arginase 1 (34.8 kD), fructose-bisphosphate aldolase B (39.5 kD), 4-hydroxyphenylpyruvate dioxygenase (45.1 kD), betaine-homocysteine methyl-transferase (45.0 kD) and KRIT1 (83.4 kD). |
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