Toxic effects of ozone on murine L929 fibroblasts. Damage to DNA. |
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| Authors: | J Van der Zee E Van Beek T M Dubbelman and J Van Steveninck |
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| Institution: | Department of Medical Biochemistry, Sylvius Laboratories, Leiden, The Netherlands. |
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| Abstract: | Damage to DNA caused by exposure of L929 fibroblasts to ozone was reflected by the generation of strand breaks, DNA inter-strand cross-links and DNA-protein cross-links. Addition of propan-2-ol, a hydroxyl radical scavenger, did not affect the formation of strand breaks. In model experiments it appeared that both purines and pyrimidines were involved in DNA inter-strand and DNA-protein cross-links. |
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