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The study of substrate specificity of a new peptide substrate of endothelin-converting enzyme |
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| Authors: | T A Gureeva E V Kugaevskaya V F Pozdnev V N Prozorovskii Yu E Eliseeva N I Solovyeva |
| Institution: | (1) Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Pogodinskaya ul. 10, Moscow, 119992, Russia |
| Abstract: | A new hexapeptide CMC-Ala-Gly-Gly-Trp-Phe-Arg was used as a substrate for assay of endothelin-converting (ECE; EC 3.4.24.71) and angiotensin-converting (ACE; EC 3.4.15.1) enzymes and of neutral endopeptidase (NEP; EC 3.4.24.11). The specific inhibitors lisinopril (for ACE) and thiorphan (for NEP) were used for discrimination between activities of these enzymes. |
| Keywords: | CMC-hexapeptide endothelin-converting enzyme angiotensin-converting enzyme neutral endopeptidase inhibitors |
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