Morphological basis for multiple interactions of ethidium bromide (EB) with yeast Candida utilis |
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| Authors: | E Keyhani |
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| Affiliation: | 1. Health Sciences Research Centre, Faculty of Health, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran;2. Department of Environmental Engineering, Faculty of Civil Engineering, Yildiz Technical University, Davutpasa Campus, 34220, Esenler, Istanbul, Turkey;3. Faculty of Health and Health Sciences Research Center, Department of Environmental Health Engineering, Mazandaran University of Medical Sciences, Sari, Iran;4. CEIT, Unit of Environmental Engineering, Paseo Manuel de Lardizábal 15, 20018 San Sebastian, Spain;5. IKERBASQUE, Basque Foundation for Science, María Díaz de Haro 3, 48013 Bilbao, Spain;6. Department of Chemistry, Indian Institute of Technology Roorkee, 247667, India;7. Department of Applied Chemistry, University of Johannesburg, Johannesburg, South Africa |
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| Abstract: | Exposure of yeast cells to EB produced multiple effects on the cellular organelles: changes in the plasma membrane characterized by 75 to 110 nm deep pits; polymorphisms of the mitochondria ranging from cup-shaped, ring-shaped, ribbon-shaped, dumbbell-shaped structures to finally the formation of very elongated mitochondria (up to 4.5 micron in length); an increase in the length and number of endoplasmic reticulum; an increase in the number of cytoplasmic vesicles whose diameter varied between 25 to 45 nm. Furthermore, EB inhibited cytochrome c oxidase and cytochrome b biosynthesis, stimulated cytochrome c biosynthesis and uncoupled oxidative phosphorylation. |
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