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Identification of a Novel Universal Potential Epitope on the Cytoplasmic Tail of H7N9 Virus Hemagglutinin |
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| Authors: | Liu Xi Ding Li Yuan Jing Liao Jian Duan Lian Wang Wenfei Tan Weiguo Yu Weiye Zhou Boping Chen Xinchun Yang Zheng |
| Affiliation: | 1.Department of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 51900, China ;2.Lab for Tuberculosis Research, Shenzhen Center for Chronic Disease Control, Shenzhen, 518020, China ;3.Department of Infectious Diseases, The Third People’s Hospital of Shenzhen (The Second Affiliated Hospital of Southern University of Science and Technology), Shenzhen, 518000, China ;4.Shenzhen Key Laboratory of Infection and Immunity, The Third People’s Hospital of Shenzhen (The Second Affiliated Hospital of Southern University of Science and Technology), Shenzhen, 518000, China ;5.Department of Pathogen Biology, School of Medicine, Shenzhen University, Shenzhen, 518000, China ;6.Longhua Branch of Shenzhen People’s Hospital, Shenzhen, 518000, China ; |
| Abstract: | This study aimed to identify a novel antigenic epitope on H7N9 virus HA7. In total, 37 patients with H7N9 infection admitted to Shenzhen Third People's Hospital between December 2012 and March 2015 were included. A library of 108 peptides covering the full-length HA7 was synthesized except for P9 and P18. Plasma samples from 11 H7N9-infected patients were tested for reactivity with the 108 synthetic peptides by peptide microarray ELISA. Results suggested that the HA7-CT epitope is a potentially antigenic epitope that could be recognized by the plasma of patients infected with influenza A virus and may drive a strong immune response after the onset of virus infection. |
| Keywords: | Influenza virus Hemagglutinin Cytoplasmic tail Antibody Epitope |
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