| Flu DRiPs in MHC Class Ⅰ Immunosurveillance |
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| 摘 要： |
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| 收稿时间： | 28 August 2018 |
Flu DRiPs in MHC Class Ⅰ Immunosurveillance |
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| Authors: | Jiajie Wei Jonathan W Yewdell |
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| Institution: | 1.Cellular Biology Section, Laboratory of Viral Diseases,National Institute of Allergy and Infectious Diseases,National Institutes of Health, Bethesda, MD 20892, USA |
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| Abstract: | Since the publication of the DRiP(defective ribosomal product) hypothesis in 1996, numerous studies have addressed the contribution of DRiPs to generating viral antigenic peptides for CD8~+T cell immunosurveillance. Here, we review studies characterizing the generation of antigenic peptides from influenza A virus encoded DRiPs, discuss the many remaining mysteries regarding the nature of their co-translational generation, and speculate on where the future might lead. |
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| Keywords: | Influenza A virus (IAV) MHC-restricted cytotoxicity Immune responses MHC class Ⅰ DRiP |
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