Inhibition of Herpes Simplex Virus-1 Replication by Natural Compound Honokiol |
| |
Authors: | Liu Shuai Li Long Tan Lingbing Liang Xiaozhen |
| |
Affiliation: | 1.University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100039, China2.Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai 200031, China |
| |
Abstract: | Honokiol is a pleiotropic natural compound isolated from Magnolia and has multiple biological and clinically relevant effects, including anticancer and antimicrobial function. However, the antiviral activity of honokiol has not yet been well studied. Here we showed that honokiol had no effect on herpes simplex virus-1(HSV-1) entry, but inhibited HSV-1 viral DNA replication, gene expression and the production of new progeny viruses. The combination of honokiol and clinical drug acyclovir augmented inhibition of HSV-1 infection. Our results illustrate that honokiol could be a potential new candidate for clinical consideration in the treatment of HSV-1 infection alone or combination with other therapeutics. |
| |
Keywords: | Honokiol Herpes simplex virus-1 (HSV-1) Viral replication Anti-viral activity Acyclovir |
本文献已被 CNKI SpringerLink 等数据库收录! |
| 点击此处可从《中国病毒学》浏览原始摘要信息 |
|
点击此处可从《中国病毒学》下载全文 |
|