Interaction of opiate peptide and noradrenalin systems: Light microscopic studies |
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Authors: | SJ Watson CW Richard RD Ciaranello JD Barchas |
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Institution: | 1. Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109 USA;1. Department of Psychiatry, Stanford University Medical Center, Palo Alto, CA 94305 USA |
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Abstract: | In this light microscopic immunocyto-chemical study β-Endorphin (β-END), leu-enkephalin and dopamine-βhydroxylase (DBH) antisera are used to obtain an overview of the interaction of the noradrenergic and opiate peptide systems in brain. Serial brain areas were analyzed for DBH and then for β-END or leu-enkephalin. Several areas were evaluated for cell and fiber interactions between these systems. The areas of richest possible contact between β-END and DBH positive systems include the rostral locus coeruleus region, the periaqueductal grey, possibly the dorsal thalamus, the paraventricular hypothalamus and the arcuate nucleus. Enkephalin cells and fibers were seen surrounding the locus coeruleus throughout its length with a few fibers in the nucleus itself. |
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Keywords: | Noradrenalin Enkephalin β-Endorphin α-MSH Brain Anatomy Immunocytochemistry |
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