ACTH accelerates recovery of neuromuscular function following crushing of peripheral nerve |
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| Authors: | Fleur L. Strand Ted T. Kung |
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| Affiliation: | 1. Department of Biology, New York University, Washington Square, New York, NY 10003 USA;1. Schering Corporation, Bloomfield, NJ 07003 USA |
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| Abstract: | Adrenocorticotropin (ACTH)-treated adrenalectomized rats subjected to crush denervation recover sensation and functional movement sooner than saline-treated rats. Axonal regeneration is accelerated, the number of large endplates and the frequency of preterminal branching are increased. ACTH has no effect on either intact or denervated muscles. The ameliorative action of ACTH during regeneration is apparently neurogenic and independent of corticoids. |
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| Keywords: | Peptide Regeneration Motor function Sensation Muscle fibers Motor endplates Axon length Protein synthesis |
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