Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene |
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| Authors: | Park Soo-Young Wang Xiaoyu Chen Zhongyi Powers Alvin C Magnuson Mark A Head W Steven Piston David W Bell Graeme I |
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| Affiliation: | Department of Biochemistry and Molecular Biology, and the Howard Hughes Medical Institute, The University of Chicago, Chicago , Illinois, USA. sooyoung@uchicago.edu |
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| Abstract: | We generated transgenic mice expressing firefly (Photinus pyralis) luciferase (luc) under the control of the mouse insulin I promoter (MIP). The mice have normal glucose tolerance and pancreatic islet architecture. The luciferase-expressing beta cells can be readily visualized in living mice using whole-body bioluminescent imaging. The MIP-luc transgenic mice may be useful for monitoring changes in beta cell function or mass in living animals with normal or altered metabolic states. |
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| Keywords: | beta cell firefly luciferase imaging insulin transgenic |
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