类风湿关节炎与痛风关节炎患者身心健康、炎症状态及免疫功能的比较

目的:比较类风湿关节炎与痛风关节炎患者身心健康、炎症及免疫状态的差异。方法:选择我院2016年5月至2018年8月收治的66例类风湿关节炎患者及63例痛风关节炎患者作为研究对象,并将之分为类风湿关节炎(Rheumatoid arthritis,RA)组及痛风关节炎(Gouty arthritis,GA)组。同时选取60例体检健康人群作为健康组。观察比较三组研究对象身心健康评分、炎症及免疫相关指标水平。结果:RA组及GA组身心健康评分显著低于健康组(P0.05),炎症及免疫相关指标水平显著高于健康组(P0.05)。RA组患者总体健康评分、社会功能评分、红细胞沉降率(ESR)、C反应蛋白(CRP)、免疫球蛋白G(Ig G)、免疫球蛋白A(Ig A)、免疫球蛋白M(Ig M)及补体3(C3)水平显著高于GA组(P0.05),白细胞(WBC)总数明显少于GA组(P0.05),两组患者生理功能、生理职能、身体疼痛、活力、情感职能、心理健康评分及补体4(C4)水平比较差异不显著(P0.05)。结论:相较于健康人群,类风湿关节炎患者及痛风关节炎患者身心健康状况差,易出现炎症、免疫功能紊乱现象,且类风湿关节炎患者炎症程度较深,免疫功能影响更大。

Comparative Analysis of the Physical and Mental Health, Inflammation and Immunity between Rheumatoid Arthritis and Gouty Arthritis

ABSTRACT Objective: To compare the different levels of physical and mental health, inflammation and immunity in patients with rheumatoid arthritis and gouty arthritis. Methods: 66 patients with rheumatoid arthritis and 63 patients with gouty arthritis admitted to our hospital from May 2016 to August 2018 were selected as subjects of study and divided into rheumatoid arthritis (RA) group and gouty arthritis (GA) group. At the same time, 60 healthy people were selected as health group. To observe and compare the physical and mental health score, inflammation and immune related indicators of the three groups of subjects and analyze them. Results: The scores of physical and mental health in RA group and GA group were significantly lower than those in healthy group (P<0.05), and the levels of inflammatory and immune related indicators were significantly higher than those in healthy group (P<0.05). The overall health score, social function score, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), immunoglobulin G (IgG), immunoglobulin A (IgA), immunoglobulin M (IgM) and complement 3 (C3) levels in RA group were significantly higher than those in GA group (P<0.05). The total number of white blood cells (WBC) in RA group was significantly less than that in GA group (P<0.05). There were no significant differences in physiological function, physiological function, physical pain, vitality, emotional function, mental health score and complement 4 (C4) level between RA group and GA group (P>0.05). Conclusion: Compared with healthy people, patients with rheumatoid arthritis and gouty arthritis have poor physical and mental health, and have inflammatory and immune disorders. And rheumatoid arthritis patients have a deeper degree of inflammation and a greater impact on immune function.