术前调强放疗联合替吉奥化疗对局部晚期直肠癌患者的疗效回顾分析

目的:探讨术前调强放疗联合替吉奥化疗对局部晚期直肠癌患者的疗效。方法:回顾性分析2012年12月至2014年12月我院收治的局部晚期直肠癌患者90例进行研究,根据治疗方法分为三组:A组(n=30)给予术前调强放疗联合替吉奥化疗治疗,B组(n=30)仅给予术前调强放疗治疗,C组(n=30)给予替吉奥化疗治疗。比较三组患者的总有效率,血清TPS、CYFRA21-1水平变化情况,1年、2年、3年复发、转移、生存率,保肛率及不良反应发生情况。结果:A组总有效率86.68%显著高于对照B组的46.67%和C组的50.00%,差异显著(P0.05);治疗前,三组TPS、CYFRA21-1水平无显著差异(P0.05);治疗后,三组TPS、CYFRA21-1水平均显著下降,且A组低于B组和C组(P0.05);三组患者1年、2年复发、转移情况无显著差异;A组3年复发、转移情况均显著低于B组和C组(P0.05);三组患者1年、2年生存率无显著差异;A组3年生存率均显著高于B组和C组(P0.05);三组患者发生恶心呕吐、白细胞减少等并发症发生情况无显著差异;A组保肛率均显著高于B组和C组(P0.05)。结论:采用术前调强放疗联合替吉奥化疗治疗局部晚期直肠癌疗效好于术前放疗。

Retrospective Analysis of the Effect of Preoperative Intensity-modulated Radiotherapy Combined with Tiogio Chemotherapy on Patients with Locally Advanced Rectal Cancer

ABSTRACT Objective: To studya retrospective analysis of the efficacy of preoperative imrt combined with tiggio chemotherapy in patients with advanced rectal cancer. Methods: A retrospective analysis of 90 patients with advanced rectal cancer admitted to our hospital from December 2012 to December 2014 was conducted. According to the treatment methods, they were divided into three groups. Group A (n=30) was given preoperative intensity modulated radiation therapy combined with teggio chemotherapy. Group B (n=30) was treated with preoperative intensity modulated radiation therapy, while group C(n=30) was given chemotherapy with teggio. The total effective rate, serum TPS, CYFRA21-1 level, recurrence, metastasis, survival rate, anus preserving rate and adverse reactions were compared among the three groups. Results: The total effective rate of group A was 86.68%, significantly higher than 46.67% of group B and 50.00% of group C, with significant difference (P<0.05); before treatment, there was no significant difference in TPS and CYFRA21-1 levels among the three groups (P>0.05); After treatment, TPS and CYFRA21-1 levels of the three groups were significantly decreased, and group A was lower than group B and group C(P<0.05); there was no significant difference in recurrence and metastasis of the three groups in one and two years; there was no significant difference in recurrence and metastasis of group A in three years (P<0.05). The three-year survival rate of group A was significantly higher than that of group B and group C (P<0.05); the three-year survival rate of group A was significantly higher than that of group B and group C (P<0.05); nausea and vomiting, leukopenia occurred in all three groups, and there was no significant difference in the incidence of complications; the anal preservation rate of group A was significantly higher than that of group B and group C (P<0.05). Conclusion: The efficacy of preoperative intensity modulation combined with tiggol in the treatment of rectal cancer was better than that of preoperative radiotherapy.